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Alterations of Axin protein expression during cardiac remodeling in rats

Li Ping, LI Jiir Liang, Yin Feng, YAN Jie, FENG Xin Heng, LI Zhao Ping, Han Qide, Zhang Youyi

Institute of Vascular Medicine，Peking Unizutsity Third Hospital，The Reference Laboratory of Education University Ministry On Molecular Cardiology，Beijing 100083

Abstract

The purpose of the present stuty was to observe the expression of Axin protein during cardiac remodeling in rats .Cardiac remodeling animal models were prepared with the methods of jugular venous notepinephrine(NE)一infusion or arterial-vein fistula(AVF).The ultrasonic parameters of rat hearts were recorded before sacrifice .The expressions of Axin protein were determined妙Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats .Cardiac concentric hypertrophy and fiSrosis was induced by 3-day jugular vein infusion of NE in rats .The expression of Axin in the left ventricles increased significantly compared with that of the control group .Cardiac eccentric hypertrophy without fibrosis was induced妙A V fistula for one week in rats，and no change in Axin protein expression in the left ventricles was obse rve d .In cultured adult rat cardiac fibroblasts，NE treatment for 24 h increased significantly the Axin protein level .It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE induced rat cardiac remodeling，which may be relevant to cardiac fibrosis.

Key words: Pathology;ventricular remodeling;Norepinephrine;fibrosis

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Citing This Article：

Li Ping, LI Jiir Liang, Yin Feng, YAN Jie, FENG Xin Heng, LI Zhao Ping, Han Qide, Zhang Youyi. Alterations of Axin protein expression during cardiac remodeling in rats. Acta Physiol Sin 2003; 55 (3): (in Chinese with English abstract).