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A ventricular pressure--clamping system for the study of mechano--electrical feedback

Wei Hua, Huang Haixia, Wang Wei, Zhang Zhifei, Fu Xiaosuo, Liu Ping, Niu Weizhen

Department of Physiology, Capital Medical University.Beijing 100069

Abstract

It is necessary to control the mechanical stimuli precisely in the studies of cardiac mechano-electrical feedback （MEF）. In the present study a ventricular pressure-clamping system has been developed, which can be applied to isolated-perfused rabbit hearts. Controlled by a computer, this system not only can make the left ventricle follow a command defining the same pressure wave as that during a beating cycle under physiological condition, but also deliver mechanical stimuli with a proper waveform to the ventricle at a particular time phase. This system integrates multiple functions, including perfusing, pacing, recording of electrocardiogram and monophasic action potentials, and clamping and measuring of ventricular pressures in isolated-perfused hearts. Thus, it is a distinct system for investigating the phenomena and mechanisms of cardiac MEF at organ level.

Key words: pressure-clamp;mechano-electrical feedback;ventricle;perfusing heart

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Citing This Article：

Wei Hua, Huang Haixia, Wang Wei, Zhang Zhifei, Fu Xiaosuo, Liu Ping, Niu Weizhen. A ventricular pressure--clamping system for the study of mechano--electrical feedback. Acta Physiol Sin 2006; 58 (6): (in Chinese with English abstract).