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I rntrarenal artery injection of L- arginine inhibits spontaneous activity of renal afferent nerve fibers

MA Hui Juan, LIU Yi Xian, WU Yu Ming, HE Rui Rong

Department of Physiology，Institute of Basic Medicine，Hebei Medical University，ShiJiazhuang 050017

Abstract

The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits .The results obtained are as follows:(1)intrarenal artery injection of L-arginine(0.05，0. 24，and 0. 48 m mol/ kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged;(2) pretreatment with a nitric oxide synthase inhibitor L- NAME(N6-nitro- L-arginine methylester，0.11 m mol/ kg)，completely abolished the effect of L-arginine;and (3) intrarenal artery injection of a nitric oxide donor SIN-1(3- morpholinosydnonimine，3. 75 umol/ kg) also resulted in an inhibition of ARNA.The results suggest that intrarenal artery injection of NO precursor(L-arginine) and donor(SIN-1)
can inhibit ARNA in anesthetized rabbits.

Key words: Physiology;L-arginine;unit- activity;renal afferent nerve

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Citing This Article：

MA Hui Juan, LIU Yi Xian, WU Yu Ming, HE Rui Rong. I rntrarenal artery injection of L- arginine inhibits spontaneous activity of renal afferent nerve fibers . Acta Physiol Sin 2003; 55 (2): (in Chinese with English abstract).