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Effect of tumor necrosis factor a on differerntiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat

LOU Shir Jie, GU Ping, XU He , XU Xiao Hui, WANG Ming Wei, He Cheng, Lu Changlin

Department of Neurobiology, Second Military Medical University, Shanghai 200433；Department of Neurology, First Hospital, Medical University of Hebei, Shijiazhuang 050013；Department of Epidemiology，Second Military Medical University，Shanghai 200433

Abstract

To observe the influence of tumor necrosis factora(TNF-a) on differentiation of rat mesencephalic neural stem cells(NS Cs)，the numbers of neurons，astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using i m munocytoche mistry technique.The
results show that:(1)TNF-a enhanced the proportions of neurons and endrocytes in progeny of NS Cs;and(2) TNF-a induced the proliferation of oligodendrocytes derived from NSCs，but the prolifer ation of astrocytes was not influenced by TNF-a.We conclude that the TNF-a could influence the application of NSCs.

Key words: neural stem cells;oligodendrocytes;differentiation ;

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Citing This Article：

LOU Shir Jie, GU Ping, XU He , XU Xiao Hui, WANG Ming Wei, He Cheng, Lu Changlin. Effect of tumor necrosis factor a on differerntiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat. Acta Physiol Sin 2003; 55 (2): (in Chinese with English abstract).