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Effects of microiontophoretically applied ADh and atropine on the electric activities of neurons in nucleus parafascicularis of thalamus in rats

Zhang Lixin, Liu Zuoyan

Department of Physiology, Tongjki Medical University. Wuhan 430030, China

Abstract

The effects of acetylcholine (ACh) and atropine on the electric activities of neurons of nucleus parafascicularis thalami (Pf) were observed in anesthetized rats with multimicropiptte technique and iontophoresis. It was found that the spontaneous and pain-induced discharges of the Pf neurons were excited and some of non-nociceptive neurons became sensitive to nociceptive stimulation with microiontophoretically applied ACh，while microiontophoretically applied atropine could diminish the spontaneous and pain-induced discharges of the Pf neurons. The effects of ACh above could be blocked by microiontophoretically applied atropine. The results show that ACh may have excitatory effects on the electric activity of the Pf neurons by M-receptor.

Key words: Acetylcholine;Atropine;Nucleus parafascicularis;Iontophoresis;Nociceptive discharges

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Citing This Article：

Zhang Lixin, Liu Zuoyan. Effects of microiontophoretically applied ADh and atropine on the electric activities of neurons in nucleus parafascicularis of thalamus in rats. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).