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Effect of D_(1) amd D_(2) dopamine receptor antagonists on acupuncture analgesia

Wang Haihong, Xu Shaofeng

Department of Neurobiology, Shanghai Medical University. Shanghai 200032, China

Abstract

Some highly selective D_(1) or D_(2),receptor antagonists were tested on rabbit skin pain model to investigate the effect of the subtypes of dopamine receptor on acupuncture analgesia. It was found that iv. of D_(2) receptor antagonists haloperidol and clozapine，had a potentiating effect on acupuncture analgesia. lcv. of D_(2) receptor antagonists domperidone and sulpiride and D_(1) receptor antagonist SCH23390, also enhanced acupuncture analgesia markedly. The effect of D_(1) and D_(2) receptor on acupuncture analgesia was discussed.

Key words: Dopamine receptor;Acupuncture analgesia;Haloperidol;Clozapine;Domperidone;Sulpiride;SCH23390

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Citing This Article：

Wang Haihong, Xu Shaofeng. Effect of D_(1) amd D_(2) dopamine receptor antagonists on acupuncture analgesia. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).