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Changes in endocochlear potential induced by potassium-channel blockers

Wang Jianli, Qian Hong, Dong Weijia, Chen Jisheng

Department of Physiology, Nanjing Bailung Medical College. Nanjing 210009, China

Abstract

The effect of various potassium-channel blockers，4-aminopyridin(4-AP)，te
traethylaminonium (TEA) and quinine，on the endocochlear potential(EP) was studied in perfused guinea pig inner ears. The fast K~(+)-channel blocker，4-AP，did not alter EP but changed its'response model to intense noise exposure. While TEA and quinine significantly reduced the amplitude of negative component of EP (N-EP)，comparing with a relatively smaller increase in general EP (G-EP).The results indicated the exis tance of different K~(+)-channels with different physiological functions.

Key words: Engocochlear potential;Potassium-channel blockers

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Citing This Article：

Wang Jianli, Qian Hong, Dong Weijia, Chen Jisheng. Changes in endocochlear potential induced by potassium-channel blockers. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).