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Effects of Mycobacterium tuberculosis infection on the transcriptional expression of human macrophage gene encoding ion channels andrelated regulatory elements

XIE Jian Ping, LI Yao, YUE Jun, XU Yong Zhong, Liang Li, Hu Changhua, YU Shan Qian'，WANG Hong Hai

State Key Laboratory of Genetic Engineering Section of Pathogen Biology, Institute of Genetics School of life Science Fuda University, Shanghai 200433；United Gene Holdings , Ltd. , Shanghai 200092；Shanghai Pulmonary Hospital, Shanghai 200433；Institute of Modern Biopharmaceuticals，School of Life Science，South west China Normal University，Chongqing 400715

Abstract

Expression microarray was employed in this study to investigate whether the ion channels and their regulatory ele ments encoding genes participate in the immune response to Mycobacteriu m tuberculosis infection .The results of a virulent strain were compared with those of the clinically isolated trains .The data demonstrate that K~(+)，Na~(+)，Ca~(+)and Cl一channels and their regulatory elements，such as the G protein，receptor and second messenger，protein kinase and protein phosphatase were involved in the immune reaction.The clinical strain affected more types of ion channels and respective regulatory elements·The data provides clues for further scrutiny into the role of ion channels and related elements in the interaction between Mycobacte riu。tuberculosis and host macrophage.

Key words: Ion channel;Receptor;expression microarray;macrophage U937;Mycobacte ri u。tuberculosis

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Citing This Article：

XIE Jian Ping, LI Yao, YUE Jun, XU Yong Zhong, Liang Li, Hu Changhua, YU Shan Qian'，WANG Hong Hai. Effects of Mycobacterium tuberculosis infection on the transcriptional expression of human macrophage gene encoding ion channels andrelated regulatory elements . Acta Physiol Sin 2003; 55 (1): (in Chinese with English abstract).