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AngiotensinⅡcornternts in plasma，and cardiac and renal tissues of sinoaortic denervated rats

SHAN Zheng Zheng, DAI Sheng Ming, FANG Feng, SU Ding Feng

Department of Pediatrics, Changhai Hospital ； Department of Pharmacology, Faculty of Basic Medicine Second Militory Medical University Shanghai 200433

Abstract

Our previous data demonstrate that impairment of arterial baroreceptor reflex(AB助plays an independent role in hypertension target organ damage .To elucidate the mechanisms responsible for the dysfunction of ABR associated organ damage，sinoaortic denervated(SAD) rats were used as an animal model of ABR dysfunction .Twentyrfourhour continuous blood pressure(SBP and DBP)，blood
pressure variability(BPV)，heart rate(H助and H R variability(HRV)were measured in conscious and unrestrained rats .Angiotensin Ⅱ(Ang Ⅱ)in plas ma，heart and kidney was assayed by raio-i m munological assay(RIA) 1 or 18 weeks after denervation.In short-term SAD rats，twenty-four hour mean SBP and DBP increased compared with that of sham-operated rats and long-term SAD rats.No significant difference in SBP，DBP or HR was found between long-term SAD rats and sham-operated ones .Compared with the sham-operated rats，long-term SAD rats had elevated BP V.No significant change in Ang 1I levels of caridiac and renal tissues was found in short-term SAD rats .In long-term SAD rats，Ang Ⅱ level of plasma was not increased while the AngⅡ content in the heart and kidney increased .Ang Ⅱ contents of plasma and tissues in long-term SAD rats exposed to chronic stress were higher than those in the control
rats .These results show(1)in short-term SAD rats blood pressure increased，while in long-term SAD rats 24 h mean blood pressure did not increase，although BPV elevated in long-term SAD rats;(2) in long-term SAD rats，secretion of Ang Ⅱ in cardiac and renal tissues was enhanced and more Ang Ⅱreleased when the animals were exposed to chronic stress.These results suggest that elevated BP V and secretion of Ang Ⅱ may be related to the development of organ damage induced by ABR dysfunction.

Key words: arterial baroreceptor reflex;blood pressure variability;Blood pressure;Angiotensin Ⅱ;rats

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Citing This Article：

SHAN Zheng Zheng, DAI Sheng Ming, FANG Feng, SU Ding Feng. AngiotensinⅡcornternts in plasma，and cardiac and renal tissues of sinoaortic denervated rats. Acta Physiol Sin 2003; 55 (1): (in Chinese with English abstract).