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#kappa#- Opioid receptor stimutation corntributes to aortic artery dilation through activation of K_(ATP) channel in the rats

PEI Jian Ming, Chen Mai, WANG Yao- Min, WEN Jun , Zhu Yunlong

Department of Physiology，Department of Cardiology，Xijing Hospital，and 3 Department of Physics，The Fourth Military Medical University, Xian 710032-

Abstract

To investigate the relaxation effect and underlying mechanism of U50 ,488 H(a selective K-opioid receptor agonist) on aorta in the rat，isolated aortic ring was perfused and the tension of the vessel was measured.It was shown:(1)K-
opioid receptor stimulation with U50 ,488H relaxed rat aorta dose-dependently;(2) the relaxation effect of U50， 488H on aorta was partially endothelium-dependent;(3) the relaxation effect of U50， 488H was significantly attenuated in the presence of glybenclamide and glipizide，two ATP-sensitive K` channel(KATP) blockers;and(4) the relaxation effect of U50，488H on vessel bore no relationship to muscariniC receptor，[r adrenoceptor，prostaglandin and nitric oxide(NO).These results indicate that K-opioid receptor stimulation with U50， 488H relaxes the aortic artery at least partially via KATP channel in
the rat.

Key words: hysiology;#kappa#-opioid receptor;aortic ring perfusion;Rat;KATP channel

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Citing This Article：

PEI Jian Ming, Chen Mai, WANG Yao- Min, WEN Jun , Zhu Yunlong. #kappa#- Opioid receptor stimutation corntributes to aortic artery dilation through activation of K_(ATP) channel in the rats. Acta Physiol Sin 2003; 55 (1): (in Chinese with English abstract).