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FAST MODULATION OF GLUTAMATE AND GABA RECEPTORMEDIATE ELECTROPI-IYSIOLOGICAL RESPONSES BY GLUCOCORTICOID

WANG WEN, XING BAO-REN , CHEN YI-ZHANG

(Institute of Neuroscience, Department of Physiology，Second Military Medical University, Shanghai 200433)

Abstract

Fast modulation by glucocorticoid on gluatmate and GABA receptor-mediated electrophysiological responses was investigated by extracellular iontophoresis and intracellular techniques in rat hypothalamic brain slices and guinea pig coeliac ganglion preparations respectively. The results were as follows:Glucocorticoid inhibited the glutamate receptor-mediated excitatory response and potentiated the GABA receptor-mediated inhibitory response within 5 min after perfusion. All these responses are reversible after removal of the glucocorticoid. Low Cat*- high Mgz+ medium was ineffective to block the fast modulatory effects of glucocorticoid on the gluatmate and GABA receptor-medi-
ated responses. It appears that the latter responses are mediated through some non-genomic mechanism without an involvement of synaptic circuitry.

Key words: Glucocorticoid;Hypothalamic slice;coeliac ganglion;Glutamate;GABA;

Received: 　　Accepted:

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Citing This Article：

WANG WEN, XING BAO-REN , CHEN YI-ZHANG. FAST MODULATION OF GLUTAMATE AND GABA RECEPTORMEDIATE ELECTROPI-IYSIOLOGICAL RESPONSES BY GLUCOCORTICOID. Acta Physiol Sin 1996; 48 (6): (in Chinese with English abstract).