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REPRESSION OF VOLTAGE GATED K+ CHANNEL EXPRESSED IN XENOPUS OOCYTES AFTER INJECTION TOTAL RNA FROM CARP RETINA BY AN ANTISENSE OLIGONUCLEOTIDE

BAO YONG-DE, Zhu Hui, ZHU XING

(Laboratory of Retina Research, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031)

Abstract

Injection of total RNA from carp retina induced the formation of a membrane K十channel in Xenopus oocytes. We found an oligonucleotide complementary to the mRNA coding for a peptide fragment in the K+ channel of drosophila and rat could sulpress the K+ channel current in a very specific manner. This provides important infomation for the cloning of this gene and for studying it's function.

Key words: oocytes of xenopus laevis;expression of RNA from carp retina; antisense oligonL cleotide;

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Citing This Article：

BAO YONG-DE, Zhu Hui, ZHU XING. REPRESSION OF VOLTAGE GATED K+ CHANNEL EXPRESSED IN XENOPUS OOCYTES AFTER INJECTION TOTAL RNA FROM CARP RETINA BY AN ANTISENSE OLIGONUCLEOTIDE . Acta Physiol Sin 1996; 48 (6): (in Chinese with English abstract).