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EFFECT OF ANGIOTENSIN II ON THE ADRENAL GLUCOCORTICOIDS SECRETION

YIN YAN-Ru , YANG GANG

(Guangzhou Medical College, PLA. Guangzhou 510315)(Deparment of Physiology, Hubei Medical University, Wuhan 430071)

Abstract

The effect of angiotensin if on adrenal cortisol secretion was studied using incubated adrenal tissues or cells preparation of guinea pig and dog. The results showed that:the cortisol secretion in guinea pigs was increased by the addition of angiotensin R in both dose-dependent and time-dependent manner at concentration> 10~(9)mol/L (P<0. O l).When ACTH was further added to the angiotensin primed preparation，the output of cortisol was further increased. Deprivation of free calcium largely suppressed the production of cortisol induced by angiotensin Ⅱ (P< 0. 05)·These resuls suggested
that angiotensin Ⅱexerts a direct effect on the secretion of adrenal cortisol，which required the presence of Ca~(2+)and is promoted by ACTH.

Key words: angiotensin B;adrenal;Cortisol;incubation

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Citing This Article：

YIN YAN-Ru , YANG GANG. EFFECT OF ANGIOTENSIN II ON THE ADRENAL GLUCOCORTICOIDS SECRETION. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).