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ANALGESIC ACTION OF MICROINJECTION OF NEUROKININ A INTO THE LATERAL RETICULAR NUCLEUS AND NUCLEUS RAPHE MAGNUS IN RATS

YAN GUO-PING, Zhao Yan, HUANG QI-E, CHEN WAN-MEI

Air Force Tianjin Hospital, Tianjin 300381)； (Xi‘an Medical University, Xi‘an 710061)

Abstract

Using the microinjection technique，the analgesic effect of neurokinin A (NKA)microinjected into the lateral reticular nucleus(LRN)and nucleus raphe magnus (NRM) was investigated in lightly pentobarbital-anesthetized rats using tail flick latency (TFL) as an index. Microinjection of NKA (0. 5 #mu#g/0. 53mu#L) into LRN significantly increased TFL lasting for 10 min (n=12，P<0. 001).Microinjection of the same amount of NKA into NRM also produced evident increase in TFL for 5 min (n=13，P<0.001).The results indicate that NKA modulates pain reaction in both LRN and NRM in rats.

Key words: neurokinin A;lateral reticular nucleus;Nucleus raphe magnus;tail flick reflex;microinjection;analgesia

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Citing This Article：

YAN GUO-PING, Zhao Yan, HUANG QI-E, CHEN WAN-MEI. ANALGESIC ACTION OF MICROINJECTION OF NEUROKININ A INTO THE LATERAL RETICULAR NUCLEUS AND NUCLEUS RAPHE MAGNUS IN RATS. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).