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EFFECT OF MICROINJECTION OF ANGIOTENSIN II INTO AREA POSTREMA ON RENAL SODIUM EXCRETIOT

PENG AI, LIN SHAN-YAN, HAO Chuan-Ming, LI PENG, ZHOU JIANG-HUA

Division of Nephrology, Huashan Hospital Shanghai Medical University, Shanghai 200040；Department of Physiology，Shanghai Medical University, Shanghai 200032))

Abstract

It has been "known that area postrema (AP) possesses angiotensin I (A I)receptors and senses directly the change of blood A ff level. The effect of microinjection of A I into the AP on renal sodium excretion was studied in the present investigation Our experimental results show that microinjection of A 1 (2，20 ng) increases GFR，RPF and UNBV (P<0. 05).These changes can be abolished by A I antagonist，saralatin and renal denervation (P<0. 05).However microinjection of A 1 (20 ng) into NTS pr叫uces no such changes. These results strongly suggest that the A I induced changes of renal hemodynamics and urine sodium excretion are mediated through AP.

Key words: area postrema;angiotensin B;renal function; microinjection

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Citing This Article：

PENG AI, LIN SHAN-YAN, HAO Chuan-Ming, LI PENG, ZHOU JIANG-HUA. EFFECT OF MICROINJECTION OF ANGIOTENSIN II INTO AREA POSTREMA ON RENAL SODIUM EXCRETIOT. Acta Physiol Sin 1996; 48 (5): (in Chinese with English abstract).