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EXPRESSION OF c-fos IN SPINAL CORD，MEDULLA OBLONGATA AND THALAMUS FOLLOWING EPICARDIAL APPLICATION OF ADENOSINE

MA Xlu-YlNG, ZHANG LIAN-SHAH, HE Rut-RONG (HO SHIU-YONG)

Departent of Physiology，Institute of Basic medicine Hebei Medical University, ShijiaJtuang 050017)

Abstract

Effects of epicardial application of adenosine on the expression of c-fos proto-oncogene in spinal cord，medulla oblongata and thalamus were examined in 12 sinoaortic denervated and vagotomized anesthetized rats. The results showed that following epicardial application of adenosine the Fos-like protein immunoreactive (FLI)neurons were remarkably increased in the dorsal horn of T3 spinal segment，nucleus paragigantocel lularis lateralis (PGL) of medulla oblongata，ventral postero-lateral thalamic nucleus (VPL)，posterior thalamic nucleus (Po)，parafascicular thalamic nucleus (PF) and centrolateral thalamic nucleus (CL)，while the blood pressure and heart rate were not affected. Onlv a few FLI neurons were found in the vehicle-control rats. The results indicate that epicardial application of adenosine may activate the pain一related neurons in spinal cord，medulla oblongata and thalamus.

Key words: adenosine;Fos protein;Spinal cord;medulla oblongata;thalamus

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Citing This Article：

MA Xlu-YlNG, ZHANG LIAN-SHAH, HE Rut-RONG (HO SHIU-YONG). EXPRESSION OF c-fos IN SPINAL CORD，MEDULLA OBLONGATA AND THALAMUS FOLLOWING EPICARDIAL APPLICATION OF ADENOSINE. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).