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A STUDY ON EXPRESSION OF THE HEAT SHOCK SUPPRESSED GENE IN DISTAL ORGANS OF RATS AFTER SCALDING

GUO XING-ZHONG, LIU YU-JIAN, WANG YI-Lun, XU REN-BAO

Department of Pathophysiotogy,Department of Biochemical Second Military Medical University, Sha咧ai 200933)

Abstract

In order to address the question whether stress in intact higher animals may inducecellular heat shock response in distal organs，the inhibition of normal gene expression was studied on the basis of our previous findings about the induction of heat shock proteins in liver and brain of rats after scalding. Male SD rats were scalded on the back，10一240 min thereafter decapitated，and the heat shock suppressed gene-1 was quantitated by dot blotting. The results showed that gene-1 decreased rapidly after scalding in
both the organs，and did not recover to control levels even 240 min after scalding. The decrease of gene-1 went parallell with the severity of scalding. Thus it may be concluded that stress may induce heat shock response of distant organs in intact animals. Possible pathological significance of these findings was discussed.

Key words: rats;burns;Stress;Heat shock response;Gene expression;messenger RNA

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Citing This Article：

GUO XING-ZHONG, LIU YU-JIAN, WANG YI-Lun, XU REN-BAO. A STUDY ON EXPRESSION OF THE HEAT SHOCK SUPPRESSED GENE IN DISTAL ORGANS OF RATS AFTER SCALDING. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).