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TISSUE CONCENTRATION AND SECRETION OF BENIN IN HUMAN PLACENTAL VILLI DURING EARLY PREGNANCY

CHEN ZHONG-KE, JIAO Li-HONG, YAN JIAN_SHE, WANG HONG

(State Key Laboratory of Reproductive Biology, Institute of Zoology, Academy Sinica, Beijing 100080；Department of Biochemistry and Molecular Biology, Life Science Faculty, Shandong Uniaaersity, Jiaurn 250100)

Abstract

In this study，tissue concentrations of renin and angiotensins in human placental villi during early pregnancy and contents of renin and angiotensin I (A I)secreted by cultured chorion were measured by radioimmunal assay (RIA).The results are as follows. During early pregnancy，the human chorion contains renin and A 1i .The activity of renin is much higher at 6th week of gestation，but as gestation proceeds，it decreases gradually，while A If shows somewhat increased change. The activity of renin secreted by cultured chorion can also be measured. A I in human placental villi can not be detected by RIA in chorion leaves or their culturing fluid. These results indicate that renin-angiotensin system may exist independently in human placental villi during
early pregnancy.

Key words: renin;angiotensin I andⅡ;Gestation;placental villi

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Citing This Article：

CHEN ZHONG-KE, JIAO Li-HONG, YAN JIAN_SHE, WANG HONG. TISSUE CONCENTRATION AND SECRETION OF BENIN IN HUMAN PLACENTAL VILLI DURING EARLY PREGNANCY. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).