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ROLE OF SUBSTANCE P IN PRESSOR RESPONSE OF CENTRAL AMYGDALOID NUCLEUS TO GLUTAMATE

LU YL-CHUM, GU (KU) YUN-Hui, LIANG Y1 , WANG Yi-GUANG

(Department of Physiology, Beijing Medical University , Beijing 100083)

Abstract

Substance P (SP)一immunoreactive cells and the axon terminals are widely distributed in the central amygdaloid nucleus (AC) and its important projection areas. The present study showed that(1)Excitation of the AC by glutamate (Glu) or injection of SP into the AC projection areas:locus coeruleus (LC)，nucleus parabrachialis (NPB)periaqueductal gray matter (PAG)or lateral hypothalamus- perifornical region (LH/PF)，all elicited pressor response.(2)Preinjection of DPDPDT (a SP antagonist) into bilateral LC，N PB，PAG or LH/PF could attenuate the AC pressor response to Glu.
(3) Intra-RVLM (rostral ventrolateral medulla)preinjection of either phentolamine，propranolol or atropine (but not GDEE，a Glu antagonist)could also reduce the AC pressor response. Taken together with our previous findings that the a-，冬，M-receptors in RVLM mediated the pressor response to LC excitation，a-receptors mediated the NPB pressor response，a- and (3-receptors mediated the PAG pressor response;these results indicate that the SPergic projections of the AC not only directly act upon the brainstem pressor areas (LC，NPB，PAG)一RVLM system，but also indirectly via the LH/PF act upon the brainstem pressor areas-RVLM system to induce the pressor response.

Key words: :pressor response;central arnygdaloid nucleus;;;

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Citing This Article：

LU YL-CHUM, GU (KU) YUN-Hui, LIANG Y1 , WANG Yi-GUANG. ROLE OF SUBSTANCE P IN PRESSOR RESPONSE OF CENTRAL AMYGDALOID NUCLEUS TO GLUTAMATE. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).