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INHIBITORY EFFECTS OF L-ENK ON THE PROLIFERATION OF CULTURED SMOOTH MUSCLE CELLS OF RATS

LI YING, LIN SHU-XIN, Wang Rui

(Departmert of Pathophysiology, Fourth Military Medical university, Xi'an 710032)

Abstract

Using method of MTT and ~(3)H-TdR incorporation，the effect of L-ENK on proliferation and DNA synthesis of the cultured thoracic aortic vascular smooth muscle cells (VSMCs) of SD rats was investigated. The results indicated that L-ENK(10~(5)一~(4)mol/L) could markedly inhibit proliferation and DNA synthesis of VSMCs，while NAL (10~(-8)--10~(-5) mol/L) had no such effect，but could antagonize the inhibitory action of L-ENK on the proliferation of VSMCs.
Key words:leucine-enkephalin (L-ENK);NAL (NAL);vascular smooth muscle cells (VSMCs)

Key words: leucine-enkephalin (L-ENK);NAL (NAL);vascular smooth muscle cells (VSMCs)

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Citing This Article：

LI YING, LIN SHU-XIN, Wang Rui. INHIBITORY EFFECTS OF L-ENK ON THE PROLIFERATION OF CULTURED SMOOTH MUSCLE CELLS OF RATS . Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).