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EFFECTS OF ANTI-rhTNFca MONOCLONAL ANTIBODY ON OXYGEN EXTRACTON IN ENDOTOXEMIC RABBITS

WU XING-YU, HAN LI-PING, ZHU MIND-GUANG, ZHANG ZHI-HONG, ZHANG LI-FAN

(Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an. 710032)

Abstract

The effects of anti一rhTNFa monoclonal antibody (McAb) on oxygen extraction in endotoxemia rabbits were observed by decreasing total oxygen delivery (D02) with progressive hypoxia. The result showed that the DOZ一VOZ relationship in anti- rhTNFaMcAb group，like the control group，could be clearly divided into "independent" and "dependent" segment，while the non-correlated antibody group，like the endotoxemic group，never presented any plateau upon breathing the air. Critical oxygen delivery (DO2C) and pooled oxygen extraction rate (ER)in anti-rhTNFa McAb group were respectively 10. 18士3. 21 ml/ (min·kg) and 0. 690，not significantly different from those in the control group(10. 18士1.69 and 0. 730).The ER in non-correlated antibody group was 0. 408，which was significantly lower than that in anti-rhTNFa McAb
group (P<0.05)，while the plasma TNFa concentration was significantly higher (P
<0. 01).It was concluded that the monoclonal antibody of recombinant human tumor necrosis factor could block or even reverse the pathologic process of oxygen extraction deficiency caused by endotoxemia.

Key words: rabbit;;;

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Citing This Article：

WU XING-YU, HAN LI-PING, ZHU MIND-GUANG, ZHANG ZHI-HONG, ZHANG LI-FAN. EFFECTS OF ANTI-rhTNFca MONOCLONAL ANTIBODY ON OXYGEN EXTRACTON IN ENDOTOXEMIC RABBITS. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).