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COMPARISON OF FUNCTIONAL #alpha#_(1)-ADRENOCEPTOR SUBTYPES IN AORTAE BETWEEN 12 MONTHAND 10 WEEK-OLD RATS

LU ZHI-ZHEN, ZHANG YOU-YI , HAN QI-DE

(Institute of Vascular Medicine, Third Hospital Beijing Medical University, Beijing 100083)

Abstract

The distribution of #alpha#_(1)-adrenoceptor and its subtypes in isolated aortae was compared between 12 month- and 10 week一old Wistar rats by determinating vasoconstrictor responses. In the 12 month-old rats, compared with the 10 week-old rats,(1)the maximal contraction induced by norepinephrine (NE) was reduced，without significant alteration of pD_(2) value;(2) the inhibitory effect of chlorethylclonidine (an irreversible antagonist for alB and alD subtype) on NE-induced contraction was weaker;(3) using NE as an agonist，the pA2 value for WB4101 (#alpha#_(1A)一and #alpha#_(1D)-selective antagonist) was not changed，but the pA2 value for BMY7378 (an alD-selective antagonist) was decreased，while the pA_(2) value for sertindole (an #alpha#_(1A)-selective antagonist) was increased.Thus，differently from the 10 week-old rats in which only #alpha#_(1A)adrenoceptors mediate NE-induced contraction in aortae，both #alpha#_(1A)and #alpha#_(1D)- adrenoceptors (mainly alA) mediate the response in the 12 month-old rats.

Key words: #alpha#_(1)-adrenoceptor;Receptor subtypes;aging;development

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Citing This Article：

LU ZHI-ZHEN, ZHANG YOU-YI , HAN QI-DE. COMPARISON OF FUNCTIONAL #alpha#_(1)-ADRENOCEPTOR SUBTYPES IN AORTAE BETWEEN 12 MONTHAND 10 WEEK-OLD RATS. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).