Issue Archive

ALTERATION OF CARDIAC#beta# ADRENOCEPTORS AND SUBTYPES WITH INCREASING AGE

LI YAN-FANG, ZHANG You-Yl, YI YONG-MEi

(Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing 100083)

Abstract

The alteration of cardiac #beta#-adrenoceptor#beta#AR and subtypes in Wistar rats of 48 and 10 weeks old were investigated by radioligand binding assay and functional determination of isolated perfused left atria. The results indicated that:(1)The density of cardiac total #Beta#-AR was downregulated about 28%in 48 weeks old rats as compared with rats of 10 weeks old for both#beta#1and #beta#2AR;(2) The sensitivity of #beta#-AR and subtypes to isoproterenol in isolated perfused atria was significantly lowered in rats of 48 weeks old.

Key words: heart;#beta#-adrenoceptor; receptor subtype;age

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

LI YAN-FANG, ZHANG You-Yl, YI YONG-MEi. ALTERATION OF CARDIAC#beta# ADRENOCEPTORS AND SUBTYPES WITH INCREASING AGE. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).