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MEDULLARY MECHANISM OF THE INHIBITION ON RENAL SYMPATHETIC EFFERENT ACTIVITIES BY STIMULATION OF THE CERVICAL VAGAL AFFERENT NERVE IN RABBITS

SU JUN-DA, HUANG ZHONG-SUN, WANG SHA-LI , LU JIE

Department of Physiology Chongqing University of Medical Science Chongqing 630046)

Abstract

Experiments were performed on 63 rabbits anesthetized with pentobarbital，paralyzed with gallamine triethiodide and ventiled artifically. lpsilateral renal sympathetic nerve discharge (RSND)，unit discharges of rostra] ventrolateral medulla (RVL)，eaudal ventrolateral medulla (CVL) and blood pressure (BP) were recorded. The sympatho-inhibitory response were evoked by stimulation of the central end of vagal nerve (CVN)(731/788 exp.).The inhibitory duration is 3. 6士0.]85 s. The responses vary with the functional state of the CNS. The RSND inhibitory duration could be shortened or prolonged，depending on the excitatory background of RSND or the basal
sympathetic tonic activity. The results, indicate that CVN一induced inhibitory of RSND may be mediated，at least partly，by excitation of NTS and CVL，which results，in turn，in depressing RVL and final reduction of sympathetic efferent activity.

Key words: sympathetic nerve discharge;vagal afferents;Nucleus tractus solitarii;rostral ventrolatoral medulla;caudal ventrolateral medulla

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Citing This Article：

SU JUN-DA, HUANG ZHONG-SUN, WANG SHA-LI , LU JIE. MEDULLARY MECHANISM OF THE INHIBITION ON RENAL SYMPATHETIC EFFERENT ACTIVITIES BY STIMULATION OF THE CERVICAL VAGAL AFFERENT NERVE IN RABBITS . Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).