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STUDIES ON GLUTAMATE AND GABA RECEPTOR EXPRESSED IN AMPHIBIAN OOCYTES AFTER INJECTION OF CARP RETINA mRNA

BAO YONG-DE, Zhu Hui, ZHU XING

(Laboratory of Retina Research Shanghai Institede of Physiology , Chinese Acadcmy of Science of Shanghai 200031)

Abstract

Using voltage clamp and perfusion technique，the types and characteristics of amino acid receptors of carp (CaTaSSin.S carrassias)retinas were studied by expressed response of amphibian oocytes previous injected with the retinal mRNA. The results were as follows:(1)Glu receptor:Diazoxide could potentiated KA induced depolarization，suggesting that some of the retinal Glu receptors may be AMPA-preferring subtype.(2)GABA receptor:Bicuculine could greatly suppress the GABA induced inward rapid current，while GABAB agonist baclofen was without effect. This suggests that the most of retinal GABA receptors may be GABA,, type.

Key words: ocytes of Xenopus laevis;mRNA of carp retina;Glu receptor (ionotropic subtypes); GABA receptor

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Citing This Article：

BAO YONG-DE, Zhu Hui, ZHU XING. STUDIES ON GLUTAMATE AND GABA RECEPTOR EXPRESSED IN AMPHIBIAN OOCYTES AFTER INJECTION OF CARP RETINA mRNA. Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).