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CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) REVERSES EXPERIMENTAL ENDOTOXIN SHOCK

ZING YI-LING , HUANG SHAN-SHENG, WANG LE-FENG, ZHANG JUN-LAN, WAN ME, HAO RONG-LI

(Institute of Basic Medical , Hebei University Shijiazhuang Department of Physiology ,Hebei Medical University Shijiazhang 050017)

Abstract

The effects of CCK一8 on the mean arterial pressure (MAP)，blood components
and path-morphological changes during endotoxin shock(endotoxin，8 mg/ kg
b. w. iv.)in rats，as well as on the 24 h mortality rate (MR)of the lead-sensitized rats in endotoxin shock一(endotoxin 1 ug/ 1'00 g b. w. iv.)were observed. The results showed that injection of CCK in ES rats led to an increase in MAP，and a reduction of hematocrit and platelet as well as white cell count;the mortality rate decreased and the lesion in main organs lessened. It is suggested that release of endogenous CCK has impor-
tant protective action during endotoxin shock.

Key words: :cholecystokinin;endotoxin shock;CCK antagonist; protective action

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Citing This Article：

ZING YI-LING , HUANG SHAN-SHENG, WANG LE-FENG, ZHANG JUN-LAN, WAN ME, HAO RONG-LI. CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) REVERSES EXPERIMENTAL ENDOTOXIN SHOCK. Acta Physiol Sin 1996; 48 (4): (in Chinese with English abstract).