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INHIBITORY EFFECT OF SUBSTANCE P OF CAUDATE NUCLEUS ON GASTRIC MOTILITY VIA SUBSTANTIA NIGRA AND DORSAL VAGAL NUCLEUS MEDIATED BY VAGUS NERVE

JING HAO, ZHANG JIAN , LIN KUN-WEI

(Department of Physiology, Dal= Medical University, Dalian 116027)

Abstract

Effects of lesion of bilateral hypothalamus (LH)，substantia nigra and dorsal vagal nucleus as well as their efferent pathway on the inhibition of gastric myoelectric fast wave and gastric motility due to injection of substance P (SP) to caudate nucleus were studied in rats. The experimental results showed that this induced inhibition was independent of the presence of intact LH but abolished by lesioning substantia nigra，dorsal vagal nucleus or vagus nerve. Depletion of sympathetic transmitter by reserpine did not affeet the occurrence of the inhibition. Thus，it appears that the gastric inhibitory effect of caudate nucleus SP is mediated via substantia nigra and dorsal vagal nucleus to vagus nerve.

Key words: Caudate nucleus; substance P;substantia nigra;dorsal vagal nucleus;gastric myoeleotric activity;gastric motility;vagus nerve ;

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Citing This Article：

JING HAO, ZHANG JIAN , LIN KUN-WEI. INHIBITORY EFFECT OF SUBSTANCE P OF CAUDATE NUCLEUS ON GASTRIC MOTILITY VIA SUBSTANTIA NIGRA AND DORSAL VAGAL NUCLEUS MEDIATED BY VAGUS NERVE . Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).