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THE RELATIONSHIP OF LATE SLOW EXCITATORY POTENTIAL WITH 5-HYDROXYTRYPTAMINE AND SUBSTANCE P IN THE GUINEA-PIG CELIAC GANGLION

PEI WEN-FEN, CAI SHENG-RONG, Zhu Yan, KONG DE-HU, HUANG ZHEN-XIN , MA RU-CHUN

partment of Physiology, Anhui Chinese Traditional Medical College, Hefei 230038；Department of Physiology, Anhui Medical University, Hefm 230032)

Abstract

The work was carried out to investigate the relationship of non- cholinergic late slow excitatory potential (LS-EPSP) with 5-hydroxytryptamine (5-HT) and substance P (SP) in the neurons of the guinea pig celiac ganglion (CG) using intracellular elee trodes in vitro. During repetitive stimulation of the splanchnic nerve (SN)，LS-EPSP following a series of action potentials could be recorded in 161 out of 206 neurons (78. 2%);Application of 5-HT and SP by superfusion or pressure ejection induced 5-HT depolarization in 102 out of 149 neurons (68. 5%)and SP depolarization in 98 out of 188 neurons(52. 1%)，respectively;Most neurons，from which LS- EPSP could be recorded during stimulation of SN，were sensitive to 5-HT (73/88，83. 0写)and SP (68八14，59.7%).However，only a small number of neurons not showing LS-EPSP during stimulation of SN were sensitive to 5-HT(10/26，38. 5%，P<0. 0001)and SP(11/36，30. 6%，P<0. 01).The results support the viewpoint that both 5-HT and SP are involved in the formation of LS-EPSP as transmitters;In adds tion，both effects of 5-HT and SP were examined in 133 neurons. There were 66 of these neurons(49. 6%)to be sensitive to both 5-HT and SP，suggesting that there
may be some functional relations between 5-HT and SP in the neurons of guinea pigCG.

Key words: Late slow excitatory postsynaptic potential;5-hydroxytryptamine;Substance P; celiac ganglion

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Citing This Article：

PEI WEN-FEN, CAI SHENG-RONG, Zhu Yan, KONG DE-HU, HUANG ZHEN-XIN , MA RU-CHUN. THE RELATIONSHIP OF LATE SLOW EXCITATORY POTENTIAL WITH 5-HYDROXYTRYPTAMINE AND SUBSTANCE P IN THE GUINEA-PIG CELIAC GANGLION. Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).