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EFFECT OF MAGNESIUM ON POSTISCHEMIC REPERFUSED MYOCARDIAL MITOCHONDRIA

XU HAI, SHI AN-YUN

(Department of Pathophysiology, Beijing Medical University, Beijing 100083)

Abstract

Isovolumic rat heart preparations were exposed to low flow ischemia(0. 2 ml/min) for 60 min，followed by 30 min of reperfusion. The concentration of MgZ+ was maintained 1. 2 mmol/L throughout the study in group 2，while increased to 15 mmol/L or depleted to zero during ischemia only in group 3 and group 1 respectively. High concentration Mgz+ showed a significantly protective effect on Ca-ATPase activity and synthesis ability of ATP in myocardial mitochondria，and decreased its calcium over.load. Thus it. appears that high concentration Mgz+ infusion may partially reverse postischemic reperfusion injury to heart.

Key words: magnesium;Myocardial ischemia;Reperfusion;Calcium;mitochondria

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Citing This Article：

XU HAI, SHI AN-YUN. EFFECT OF MAGNESIUM ON POSTISCHEMIC REPERFUSED MYOCARDIAL MITOCHONDRIA. Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).