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Methods for single unit recording in behavioring morphine craving rat

Liu Suqing, Wu Jing, Yang Jianzhen, Tian Shaohua, Chen Nanhui, Lei Yanlin, Peng Yanping, Wang Jianhong, Ma Yuanye

Section of Primates Cognitive Brain Research,Kunming Institute of Zoology,the Chinese Academy of Sciences.Kunming 650223,Yunnan

Abstract

In this paper, one method was introduced, which was a combination of the cue-related morphine addiction model and a technique for obtaining chronic extracellular recordings of single units in freely moving rats. With the combination and improvement of this technique, We have successfully applied this new method to study the neuronal activity of the hippocampus CA1 region in morphine withdrawal rats. In all, we found some more accurate and objective cellular characteristics of hippocampal neurons, and considered these characteristics as one of electrophysiological indexes of morphine addiction rats.

Key words: Single unit recording;Freely moving rat;cue-related;Morphine withdrawal;Hippocampus

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Citing This Article：

Liu Suqing, Wu Jing, Yang Jianzhen, Tian Shaohua, Chen Nanhui, Lei Yanlin, Peng Yanping, Wang Jianhong, Ma Yuanye. Methods for single unit recording in behavioring morphine craving rat. Acta Physiol Sin 2004; 56 (6): (in Chinese with English abstract).