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Comparative studies of vasodilating effects of angiotensin--(1--7) on the different vessels

Zhi Jianming, Chen Rongfang, Wang Jin, Jiao Xiangying, Zhao Rongrui

Department of Physiology,Shanghai Second Medical University.Shanghai 200025；China；Department of Physiology,Shanxi Medical University.Taiyuan 030001,Shanxi

Abstract

The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dosedependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT_(1) or AT_(2) receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.

Key words: angiotensin;vasorelaxation;receptor

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Citing This Article：

Zhi Jianming, Chen Rongfang, Wang Jin, Jiao Xiangying, Zhao Rongrui. Comparative studies of vasodilating effects of angiotensin--(1--7) on the different vessels. Acta Physiol Sin 2004; 56 (6): (in Chinese with English abstract).