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CHANGES IN DENSITIES OF HYPOTHALAMIC u OPIOID RECEPTOR DURING CUPRIC ACETE-INDUCED PREOVULATORY LH SURGE IN RABBIT

YANG SHU-PING, HE LIAN-FANG, Yu Jin

(oa/c)'-N'从u7"，Shan咖:Medical University, Shanghai 200011；Department of Neurobiology，Shanghai Medical University, Shanghai 200032)

Abstract

Decrease in activity of hypothalamic卜endorphin(日一EP) is an important factor for inducing the preovulatory LH surge. To study whether hypothalamic p opioid receptor is involved in this process，changes in densities of hypothalamic p opioid receptors were observed in this study by autoradiography and image process during cupric acetate (CuAC)-induced preovulatory LH surge in rabbits. New Zealand female rabbits were injected 1%CuAC 0. 9 ml or saline 0. 9 ml and sacrificed at different times after the injection. The densities of a opioid receptor in the medial basal hypothalamus (MBH) and the medial preoptic area (MPO) were measured. A transient increase in densities of
MPO p opioid receptor were observed 1 h after CuAC injection (P<0. 05).The densities of MPO p opioid receptor decreased significantly before the onset of the LH surge(P<0. 05) and remained at a low level during the surge. The change in densities of popioid receptor in the MBH was similar to those in the MPO. No change was observed in the saline control group. There was a negative correlation between the changes in densities of MBH p opioid receptor and serum LH levels in the process of LH surge. The results suggest that the decrease of hypothalamic p opioid receptor may be involved in
the preovulatory LH surge.
Key words:preovulatory LH surge;w opioid receptor;hypothalamus;rabbit;cupric acete

Key words: Key words:preovulatory LH surge;#mu#-opioid receptor;Hypothalamus;;

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Citing This Article：

YANG SHU-PING, HE LIAN-FANG, Yu Jin. CHANGES IN DENSITIES OF HYPOTHALAMIC u OPIOID RECEPTOR DURING CUPRIC ACETE-INDUCED PREOVULATORY LH SURGE IN RABBIT . Acta Physiol Sin 1997; 49 (3): (in Chinese with English abstract).