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EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS

YU GUANG-DI, WEI XIAO-PING, ZHANG HUI-QIN, XU SHUANG, YIN QI-ZHANG, TANG PAK-L , MAN ZHONG-MING

(Laboratory of Neurobiology, Suzhou Medical College, Suzhou 215007)

Abstract

The effect of dorsal raphe nucleus (DR)stimulation on the unit discharge of
suprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically in the Wistar rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically，this inhibition could be enhanced by monoamine oxidase inhibitor pargyline，attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorophenylalanine and blocked by 5-HTrecepor antagonist cyproheptadine. It was suggested that the inhibitory effect of DR stimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.

Key words: Key words:suprachiasmatic nucleus; light-snsitive neuron;cypro- heptadine;;;

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Citing This Article：

YU GUANG-DI, WEI XIAO-PING, ZHANG HUI-QIN, XU SHUANG, YIN QI-ZHANG, TANG PAK-L , MAN ZHONG-MING. EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS . Acta Physiol Sin 1997; 49 (3): (in Chinese with English abstract).