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NOREPHINEPHRINE REGULATION OF T-LYMPHOCYTE PROLIFERATION OF RAT DURING ACUTE HYPOXIA

BAI HAl_Bo, DU Jl_ZENC

(Northwest Plateau Institute of Biology，Chinese Academy of Sciences, Xining 810001

Abstract

Interaction between the immune and neuroendocrine systems has long been not-
ed. In the present study，the role of norepinephrine (NE) in immunoregulation of rats during simulated hypoxia in hypobaric chamber was examined. It was found that 7 km for 24 h of hypoxia inhibited T-lymphocyte proliferation by 41%.7 d and 20 d of hypoxia，simulating 5 km altitude，reduces T-lymphocyte proliferation respectively 34% and 6 0%.Intracerebroventricular (icv) injection of 5 X 10一6 mol/L NE decreased T lymphocyte proliferation by 29%.ICV injection of phentolamine 25 4g/rat prior to 7km for 10 h hypoxia attenuated the hypoxia-induced suppression of T-lymphocyte proliferation from 42%to 21%.In additon，7 km 10 h hypoxia increased CRF levels in
blood and catecholamines in hypothalamus. An increased circulation CRF level was also noted after NE injection (icv) of 5 X 10一“mol/L. Hypoxia corresponding 7 km altitude for 10 h stimulates spleen一lymphocytes incubated with CRF，but T-lymphocyte proliferation decreclsed with increasing CRF concentration. These findings suggest that hypoxia inhibits T-lymphocyte proliferation probably through an immune inhibition action by
CRF-NE.

Key words: hvnmcia;T-lvmnhncvte nrnliferatinn;NF;immunnreeulatinn:CRF

Received: 　　Accepted:

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Citing This Article：

BAI HAl_Bo, DU Jl_ZENC. NOREPHINEPHRINE REGULATION OF T-LYMPHOCYTE PROLIFERATION OF RAT DURING ACUTE HYPOXIA. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).