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EFFECT OF MICROINJECTION OF GABA INTO THE CAUDADE NUCLEUS ON ELECTRICAL DISCHARGES OF NOCICEPTIVE NEURONS IN CAUDATE NUCLEUS OF RAT

GU Rui min, SUN Min-zhi, Li Yu-rong, ZHANG JI_YE, HAN WEI-MIN, LIU GANG

(Department of Physiology, Harbin Medical University, Harbin 150086)

Abstract

The characteristics of glass microelectrode recorded electrical activity of nociceptive neurons in the caudate nucleus elicited by microinjection of GABA and blockage by picrotoxin (PIC) were studied in 53 Wistar rats. The results showed that GABA (25，50，]00 4g/2 41 every 2 min) inhibited the activity of pain excitation neurons (PEN)，as shown by decreased frequency and increased latency，but enhanced the activity of pian inhibition neurons (PIN)，as shown by shortened duration and increased discharge frequency. Both activities are highly dose-dependent and could be blocked by PIC (ip
250 }ig，1 ml/1 min).

Key words: caudate nucleus;neuron;;;;

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Citing This Article：

GU Rui min, SUN Min-zhi, Li Yu-rong, ZHANG JI_YE, HAN WEI-MIN, LIU GANG. EFFECT OF MICROINJECTION OF GABA INTO THE CAUDADE NUCLEUS ON ELECTRICAL DISCHARGES OF NOCICEPTIVE NEURONS IN CAUDATE NUCLEUS OF RAT. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).