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CHANGES IN THE EXPRESSION OF #alpha#- AND #beta#-MYOSIN HEAVY CHAIN GENE DURING THE DEVELOPMENT OF RENAL HYPERTENSION IN RATS

ZHENG HUI, PAN JING-YUN, Ll HONG-YI, ZHOU XIAO-NAN

(Department of Physiology, Sun Yat-Sen Medical University, Guangzhou 510089)

Abstract

The changes in the expression of cardiac a- and (3-myosin heavy chain (MHC)
gene of the left ventricle were investigated in two-kidney，one-clip(2KIC)renal hypertensive rats. The results were as follows:(1)When blood pressure was increased，the left ventricle became hypertrophic，#alpha#- MHC gene expression was reduced and#beta#MHC gene expression was increased in 2K 1 C renal hypertensive rats. (2) When the animal was treated with captopril，angiotensin converting enzyme inhibitor 4 W after operation and then 8 W with removal of the ischemic kidney，the blood pressure was decreased with attendant regression of left ventricular hypertrophy，while the increase in
#beta#MHC mRNA level was attenuated and the inhibition of a-MHC mRNA level was reduced. The above results suggest that the rise in arteral pressure is an important factor in the left ventricular hypertrophy and the MHC gene switch. Renin angiotension system may be involved in the cardiac hypertrophic and MHC gene switch during the development and maintenance of 2K 1 C renal hypertension.

Key words: hypertrophy;;renal hypertension ;

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Citing This Article：

ZHENG HUI, PAN JING-YUN, Ll HONG-YI, ZHOU XIAO-NAN. CHANGES IN THE EXPRESSION OF #alpha#- AND #beta#-MYOSIN HEAVY CHAIN GENE DURING THE DEVELOPMENT OF RENAL HYPERTENSION IN RATS. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).