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A STUDY ON THE CHANGE OF MYOCARDIAL NEUROPEPTIDE Y RELEASE INDUCED BY ELECTRIC STIMULATION AND MYOCARDIAL ISCHEMI IN GUINEA PIG HEARTA

Yang Xiongli

(Shanghai Insititute of Physiology, Shanghai Joint Laboratory of Life Science, Chinese Academy of Seiences, Shahghai 200031)

Abstract

Electrical stimulation of the left stellate ganglion in guinea pig heart evoked a calcium-dependent，exocytotic release of neuropeptide Y (NPY).Stimulation after 10 min of global ischemia (S2)，compared with control period stimulation (S1)，had no signifcant effect on the NPY release. The release of NPY produced by the same stimulation ifter 20 min of ischemia was inhibited to certain extent (S2/S1:0.72，PC0. 05)，whereas the inhibition of NPY release disappeared after 5 min of reperfusion (with a S2/S1 of 1. 01).Ischemia alone，without electric stimulation，did not apparently in-
duce NPY release，suggesting that electrical stimulation may induce a calcium-dependent, exocytotic release of NPY. It is further suggested that the inhibion of NPY release may be produced by some metabolites and the abolishment of the inhibion after reperfusionmay be due to washout of the metabolites.

Key words: neuropeptide Y;Myocardial ischemia; electrical stimulation

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Citing This Article：

Yang Xiongli. A STUDY ON THE CHANGE OF MYOCARDIAL NEUROPEPTIDE Y RELEASE INDUCED BY ELECTRIC STIMULATION AND MYOCARDIAL ISCHEMI IN GUINEA PIG HEARTA. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).