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EFFECTS OF AMILORIDE AND GLYCOGEN DEPLETION ON POST-ISCHEIV耳C REPERFUSION INJURY OF ISOVOLUMIC PERFUSED RAT HEARTS

Zhao Tingcun, Zhang Xiuling, Shi Anyun, Xu Hai

(Department of Pathorphysiology Xinximcg Medical College, Xinxiang 453003)；(DWtmed of Pathophysiology, Beijing Mediatl University, Beijing 100083)

Abstract

The efftcts of amiloride (0. 5 nmol/L) and glycogen depletion were studied to find out the possible roles of Na+-H+ exchange of ischemia reperfusion injury in the isovolumic perfused isolated rat hearts. The data indicated that, compared to control group，both amiloride and glycogen depletion accelerated recovery of hemodynamics and reduced leakage of LDH and the formation of myocardial MDA which was accompared by a higher activity of mitochondrial GSH-Px and lesser accumlation of intracellular Na+，Cal+. That Na+-H+ and Na+-Cal+ exchanges might play a critical role in postischemic reperfusion injury is discussed.

Key words: Key words:amiloride;reperfusion injury;Na~(+)-Ca~(2+ )exchange ;;

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Citing This Article：

Zhao Tingcun, Zhang Xiuling, Shi Anyun, Xu Hai. EFFECTS OF AMILORIDE AND GLYCOGEN DEPLETION ON POST-ISCHEIV耳C REPERFUSION INJURY OF ISOVOLUMIC PERFUSED RAT HEARTS. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).