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EFFECTS OF 5-HT ON ACTIVITY OF ARCUATE NEURONS OF RAT HYPOTHALAMIC SLICES

Tao Ping, Mei Jun

(Departmnt可Brain meal Nerve, Xian Medical University, Xian 710061)

Abstract

Extracellular recordings were made from 176 spontaneous discharging units in the arcuate nucleus of rat hypothalamic slices. Depending on the patterns of discharge，the units were divided into three types;slow irregular (76%)，fast continuous (26. 5%) and phasic units(6. 3%).The effect of 5-HT on the different types of units were observed. The results indicated that most of neurons were inhibited by 5-HT，and only a small portion of the cells showed excitation and a few of the slow irregular units showed "excitation after inhibition".With 5-HT 10一6 mol/L we found that 12 units inhibited by 5-HT could not be reversed by CHD，while the 4 inhibited units could be partly or completely reversed by MSG. 4 of the 7 neurons inhibited by 5-HT were part-
1y blocked by Pindobind-5-HTIA but not for the remaining 3 neurons. The results suggest that the inhibitory effect of 5-HT on arcuate neurons may be mediated by 5-HTl receptor，while some by 5-HTIA receptor.

Key words: arcuate neuron;Serotonin;cyproheptadine;methysergide;pindobind-5-TIA

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Citing This Article：

Tao Ping, Mei Jun. EFFECTS OF 5-HT ON ACTIVITY OF ARCUATE NEURONS OF RAT HYPOTHALAMIC SLICES. Acta Physiol Sin 1996; 48 (2): (in Chinese with English abstract).