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AUTORADIOGRAPHIC APPROACH TO THE DEVELOPMENTAL STUDY ON THE BINDING SITES OF AVP_(4-8) IN RAT HIPPOCAMPUS

Section of Primates Cognitive Brain Research,Kunming Institute of Zoology,the Chinese Academy of Sciences.Kunming 650223,Yunnan

Abstract

The localization of the "S-labelled AVP4-8 binding sites in the rat hippocampus was studied by using autoradiographic approach via observing the selective damages of hi_p-pocampal neurons by neurotoxins，and the developmental regulation of the hippocampalAVP4-8 receptor by pretreatment with exogenous AVP4-8 was observed. In adult rat hippocampus，the binding sites of AVP4-8 were assembled on the whole hippocampal pyramidal cell layer and granular cell layer of the dentate gyrus. Treatment of colchicine caused parallel disappearances of granular cells and the AVP4-8 binding sites in the
gyrus，while treatment of kaininc acid destroyed the CA3-CA4 pyramidal cell layer and abolished the binding sites in this area. The developmental emer -nces of AVP4-8 bind ing sites were normally on postnatal day 6 in pyramidal cell layer and postnatal day 7 in the dentate gyrus. However，postnatal daily treatments of exogenous AVP4-8 enhanced the formations of both pyramidal and dentate binding sites，as they appeared rather densely on postnatal day 5. The characterized distribution of AVP4-8 binding sites in the rat hippocampus and the relationship between their developmental enhancements and facilitation of learning behaviors in mature rat by neonatal treatment of exogenous
AVP4-8 were discussed.

Key words: binding site;;

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Citing This Article：

. AUTORADIOGRAPHIC APPROACH TO THE DEVELOPMENTAL STUDY ON THE BINDING SITES OF AVP_(4-8) IN RAT HIPPOCAMPUS. Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).