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ClC-3 expresion in the cell cycle of nasopharyngeal carcinoma cells

Wang Liwei, Chen Lixin, Jacob T

Department of Physiology and Laboratory of Cell Biology,Guangdong Medical College.Zhanjiang 524023,Guangdong；UK

Abstract

The results indicated that CNE-2Z cells expressed ClC-3. ClC-3 was located predominantly inside the cells but not in the membrane. Both the expression level and the distribution of ClC-3 were cell cycle dependent. ClC-3 expression was low in G1 but high in S phase. The cells in G2/M phase possessed an intermediate level of the expression. ClC-3 expression level was negatively correlated to the RVD capacity and amplitude of the volume-activated chloride current in the cell cycle. The results suggest that ClC-3 may be an important factor in the regulation of cell cycle progression, but that it is probably not the chloride channel associated with RVD in these cancer cells.

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Citing This Article：

Wang Liwei, Chen Lixin, Jacob T. ClC-3 expresion in the cell cycle of nasopharyngeal carcinoma cells. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).