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The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus

Li Tianfu, Luo Yumin, Lu Chuanzhen

Department of Neurology,Huashan Hospital,Fudan University.Shanghai 200040

Abstract

These results suggest that seizures lead the translocation of Smac/DIABLO into the cytosol, the activation of caspase-9 and the change of subcellular locoalization of XIAP. These changes may play a role in the brain damage induced by seizures. Caspase-9 is possibly a potenmtial therapeutic target in the treatment of brain injury associated with seizures.

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Citing This Article：

Li Tianfu, Luo Yumin, Lu Chuanzhen. The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).