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Temporal and spatial distribution of VIP, CGRP and their receptors in the development of airway hyperresponsiveness in the lungs

Ren Yanhong, Qin Xiaoqun, Guan Chaxiang, Luo Ziqiang, Zhang Changqing, Sun Xiuhong

Department of Physiology,Xiangya Medical School,Central South University.Changsha 410078,Hunan

Abstract

From the results, it is concluded that ozone-stressing can induce the development of AHR, in which VIP and CGRP may play important roles. That implies, through binding to CGRPR1, CGRP stimulates an early inflammation response which contributes in cleaning up of irritants, while VIP exerts a later dampening of pulmonary inflammation response. These two neuropeptides may play sequential and complementary roles in the development of AHR.

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Citing This Article：

Ren Yanhong, Qin Xiaoqun, Guan Chaxiang, Luo Ziqiang, Zhang Changqing, Sun Xiuhong. Temporal and spatial distribution of VIP, CGRP and their receptors in the development of airway hyperresponsiveness in the lungs. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).