Issue Archive

Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus

Zhang Chunyi, Shen Wanhua, Zhang Guangyi

Research Center for Biochemistry and Molecular Biology,Xuzhou Medical College.Xuzhou 221001,Jiangsu

Abstract

The results demonstrate that the release of cytochrome c from mitochondria to cytosol and the up-regulation of Bcl-2 are possibly mediated by NMDA receptors or L-VGCC following brain ischemia. Cytochrome c release may be injurious while Bcl-2 up-regulation may be protective to ischemic hippocampus.

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Zhang Chunyi, Shen Wanhua, Zhang Guangyi. Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).