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Dual action of lysophosphatidic acid in cultured cortical neurons: survival and apoptogenic

Zheng Zhaoqing, Fang Xianjun, Qiao Jiantian

Department of Neurobiology,Shanxi Medical University.Taiyuan 030001,Shanxi；USA

Abstract

The results showed that administration of LPA at lower concentrations (0.1-30 #mu#mol/L) dose-dependently protected cortical neurons from apoptosis that was induced by deprivation of serum from the cultural medium, while 50 #mu#mol/L or higher concentrations of LPA failed to show this effect; and moreover, the concentrations higher than 50 #mu#mol/L induced apoptosis in neurons cultured in serum-containing complete medium. These results suggest that a moderate concentration of LPA may play as a survival factor in apoptotic cortical neurons, while an excessive level of LPA induces apoptosis in neurons cultured in complete medium.

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Citing This Article：

Zheng Zhaoqing, Fang Xianjun, Qiao Jiantian. Dual action of lysophosphatidic acid in cultured cortical neurons: survival and apoptogenic. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).