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The protective effect of basic fibroblast growth factor (bFGF) and electroacupuncture on neurons against cerebral ischemia

Li Rong, Guo Jingchun, Cheng Jieshi

National Key laboratory of Medical Naurobiology, Institute of Acupuncture Research, Shanghai Medical College, Fudan University.Shanghai(200032)

Abstract

Transient cerebral ischemia/reperfusion rat model was adopted, and the method of H&E staining, TUNEL staining (TdT-mediated dUTP Nick End Labeling) were used to observe the effect of electroacupuncture (EA) and basic fibroblast growth factor (bFGF) on neuronal death. The result evinced that the combination of EA and bFGF could evidently reduce the neuronal death, including both necrosis and apoptosis, compared with EA or bFGF application alone. It is suggested that bFGF and EA can complement each other and enhance the protective effect following cerebral ischemia.

Key words: Cerebral ischemia/reperfusion;Electroacupuncture(EA);Basic fibroblast growth factor (bFGF);Neuro-protective effect

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Citing This Article：

Li Rong, Guo Jingchun, Cheng Jieshi. The protective effect of basic fibroblast growth factor (bFGF) and electroacupuncture on neurons against cerebral ischemia. Acta Physiol Sin 2002; 54 (4): (in Chinese with English abstract).