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The correlations between plasma TNF-#alpha#, NO, NOS levels and brain lateralization in mice

Fu Qingling, Li Kangsheng

Department of Microbiology and Immunology,Shantou University Medical College.Shantou 515031,Guangdong

Abstract

The results showed that (1) in the normal mice, ambidextrous mice had higher NO levels compared with left-pawed mice (P<0.05). After the injection of LPS, plasma level of TNF-#alpha# was lower in left-pawed mice compared with those of the right-pawed and ambidextrousmice; plasma level of NO was higher in ambidextrous mice compared with those of the right-(P<0.01) and left-pawed (P<0.05) ones, and there was no significant difference in the plasma levels of NOS among ambidextrous, right- and left-pawed mice. (2) Immune parameters were correlated with the RPE scores. The shape of the curve describing this relation was similar to a parabola. In general, the levels of TNF-#alpha#, NO, NOS rose along with increase of RPE if the scores were in the score range of left-pawed mice. After that, they reached a peak if the scores were in the score range of ambidextrous mice. Then they declined along with the increase of RPE if the scores were in the score range of right-pawed mice. In conclusion, plasma levels of TNF-#alpha#, NO and NOS were associated with brain lateralization, suggesting that the activaties of Mo/M#PHI# were influenced by brain lateralization, and that the immune parameters were correlated with the RPE scores.

Key words: Brain lateralization;Immunomodulation;Tumor necrosis factor-#alpha#;Nitric oxide;nitric oxide synthase;Macrophage

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Citing This Article：

Fu Qingling, Li Kangsheng. The correlations between plasma TNF-#alpha#, NO, NOS levels and brain lateralization in mice. Acta Physiol Sin 2002; 54 (6): (in Chinese with English abstract).