Issue Archive

Effects of total body irradiation injury on the participation of dermal fibroblasts in tissue repair

Qu Jifu, Cheng Tianmin, Xu Linshui, Shi Chunmeng, Ran Xinze

Institute of Combined Injury of PLA,Third Military Medical University.Chongqing 400038；China

Abstract

The results showed that the abilities of proliferation, attachment and adhesion of fibroblasts isolated from wounds combined with TBI injury significantly decreased as compared with those of simple incision injury, nevertheless, apoptotic ratio of fibroblasts isolated from wounds combined with TBI injury increased significantly. These data suggest that TBI injury may cause direct damaging effects on fibroblasts in wounds, which might be one of the dominant reasons for impairment of wound healing when it is combined with TBI injury.

Key words: Fibroblasts;Tissue repair;Wound healing;Total body irradiation injury

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Qu Jifu, Cheng Tianmin, Xu Linshui, Shi Chunmeng, Ran Xinze. Effects of total body irradiation injury on the participation of dermal fibroblasts in tissue repair. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).