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Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats

Shi Yanrong, Qi Yongfen, Bu Dingfang, Gao Lin, Wang Dongyan, Jiang Hongfeng, Pang Yongzheng, Tang Chaoshu

Institute of Cardiovascular Disease Research,The First Hospital of Peking University.Beijing 100034

Abstract

The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (V_(max)) of taurine transportration in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.

Key words: Taurine;Transporter;mRNA;Spontaneously hypertensive rat;Myocardial;Vessels

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Citing This Article：

Shi Yanrong, Qi Yongfen, Bu Dingfang, Gao Lin, Wang Dongyan, Jiang Hongfeng, Pang Yongzheng, Tang Chaoshu. Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).