ISSN 0371-0874, CN 31-1352/Q

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Effect of angiotensin Ⅱ on L-type calcium channel in ischemic ventricular myocytes of the guinea pig

Wang Wenwei, Zhu Yichun, Yao Tai, Zheng Ping, Gong Qianling

Department of Physiology,Shanghai Medical College of Fudan University,National Key Laboratory for Medical Neurobiology.Shanghai 200032

Abstract

Using whole cell patch clamp, the effects of angiotensin II (Ang II) on the current L-type calcium channel (I_(Ca,L)) were observed in guinea pig isolated ventricular myocytes under simulated ischemia condition, which was realized through hypoxia, glucose deficiency, high lactic acid and acidosis.. The results showed that, under the condition of simulated ischemia, the peak of L_(Ca,L) was reduced with maximal activation potential at 0 mV. Administration of Ang II (100 nmol/L) enhanced the peak of I_(Ca,L) during ischemia and shifted the maximal activation potential to -10 mV. The possible mechanism of these effects is discussed.

Key words: Angiotensin II;Myocardial ischemia;Whole cell pacth clamp;L-type calcium channel

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Citing This Article:

Wang Wenwei, Zhu Yichun, Yao Tai, Zheng Ping, Gong Qianling. Effect of angiotensin Ⅱ on L-type calcium channel in ischemic ventricular myocytes of the guinea pig. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).